Europe

BiGR

Acronyme ou nom de la structure: 
Nom complet (en toutes lettres): 
Bioinformatics platform, Gustave Roussy
Adresse: 
Plateforme de bioinformatique BiGR UMS AMMICA INSERM US23 / CNRS UMS3655 PF de l'Institut Français de Bioinformatique (IFB) Bâtiment B2M - étage 1 - pièce 136 114, rue Édouard-Vaillant 94805 Villejuif Cedex - France
Téléphone: 
0142114112
SFBI: 
0

DINMP

Acronyme ou nom de la structure: 
Nom complet (en toutes lettres): 
Biophysique théorique et Biologie des Systèmes
Adresse: 
DIMNP - UMR 5235 CNRS/UM1/UM2 Pl. E. Bataillon - Bat. 24 Université Montpellier CP 107 34095 Montpellier Cedex 5 FRANCE
Téléphone: 
+33-(0)4-6714-9221
Fax: 
+33-(0)4-6714-4286
SFBI: 
0

BF2I

Acronyme ou nom de la structure: 
Nom complet (en toutes lettres): 
Atelier de Bioinformatique
Adresse: 
INSA Bâtiment Louis Pasteur 20 avenue Albert Einstein 69621 Villeurbanne cedex
Téléphone: 
+33 (0)4 72 43 83 56
Fax: 
+33 (0)4 72 43 85 34
Description (English): 

Research at BF2I is focused on the comprehension of the functions managing the interaction of specific insect pests (aphids and weevils) with their direct biological partners (host plants and symbiotic microorganisms). Research approaches are multi-disciplinary thanks to the different expertise of the staff members.

The central theme of our research is to understand the relationships established between insects and their symbionts elucidating the molecular mechanisms that allow the establishment, maintenance and persistence of these complex interactions in multiple insect generations.

The final goal of research on these complex biological interactions, often involving multiple partners in interaction with the environment, is to identify tools and define new concepts for an integrated approach for plant protection against insect pests. Our research results are to be central for the development of agricultural practices that are sustainable, and respect both the environment and human health.

English keywords: 
symbiosis, insect pests, functional genomics, systems biology
SFBI: 
Membre de la SFBI

Impact systémique des petits ARN régulateurs

Acronyme ou nom de la structure: 
Nom complet (en toutes lettres): 
Impact systémique des petits ARN régulateurs
Adresse: 
141 rue de la Cardonille 34396 Montpellier
Téléphone: 
04.34.35.99.36
Description (English): 

MicroRNAs ("miRNAs") are small post-transcriptional regulators. The function of these small RNAs in animals has been well characterized at a molecular level, but their role is less well known at the macroscopic scale: how could miRNAs have any biological function if they repress most of their targets less than 2-fold (while inter-individual gene expression fluctuation typically exceeds 2-fold, and is buffered by homeostatic mechanisms)?
According to the current dogma, each miRNA regulates tens or hundreds of targets, yet several observations suggest miRNAs have a much weaker impact on animal biology. We recently proposed an alternative hypothesis: most identified "targets" are not repressed enough by the miRNA to yield physiological consequences; these genes would rather act as competitive inhibitors, preventing the miRNA from interacting with its few, real targets. The only difference between real targets and competitive inhibitors would be the sensitivity of their biological activity to the modest repression guided by miRNAs. Hence the role of miRNAs in integrated phenomena should be assessed using a systems biology approach.
We are now testing directly the new hypothesis, assessing several of its predictions. We aim at providing the first quantitative analysis of miRNA action in vivo and an improvement in miRNA target identification (taking into account the extent of predicted repression and the robustness of affected biological pathways).
More generally, we are proposing a new vision of gene regulation: a regulatory target is not simply a gene that is affected by a regulatory pathway; it is a gene that is affected enough by the pathway - the extent of a measured regulation needs to be confronted to the robustness of biological systems to fluctuations.
 

English keywords: 
microRNA, systems biology, pseudo-targets
SFBI: 
0

Glycogénomique

Acronyme ou nom de la structure: 
Nom complet (en toutes lettres): 
Glycogénomique
Adresse: 
163 Avenue de Luminy 13288 Marseille
Téléphone: 
+33-(0)491-825-587
SFBI: 
0
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