Postdoctoral position in population genomics of transposable elements IBENS, Paris, France

Type de poste
Dates
Durée du poste
Contrat renouvelable
Contrat non renouvelable
Date de prise de fonction
Date de fin de validité de l'annonce
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Institut de Biologie de l&#39;Ecole Normale Supérieure (IBENS)
CNRS UMR8197 - INSERM U1024
46 rue d&#39;Ulm

75230 PARIS CEDEX 05

France

Contacts
Quadrana Leandro
Email du/des contacts
quadrana@biologie.ens.fr
Description

<p>Applications are invited for a Postdoctoral Researcher to join our team (<a href="https://www.ibens.ens.fr/spip.php?rubrique37">https://www.ibens.ens.fr/…;) at the Institut de Biologie de l&rsquo;Ecole Normale Supérieure (IBENS) in Paris. IBENS is located in the heart of Paris and is part of the Montagne Sainte-Geneviève campus, which hosts the largest concentration of research institutions in the city. IBENS carries out fundamental research of the highest level in biology, with a strong emphasis on interdisciplinarity (<a href="https://www.ibens.ens.fr/">https://www.ibens.ens.fr/</a&gt;). Our team investigates the contribution of transposable elements (TEs), together with the epigenetic mechanisms that control their activity, to the generation of heritable phenotypic variation. We use plants as models to address questions at the whole genome level through molecular, genetic and computational approaches.</p><p>&nbsp;</p><p><strong>The project</strong>: The successful candidate will join a project aimed at modeling the impact of climate change on TE activity. Specifically, we first wish to identify potential &ldquo;transposition bursts&rdquo; associated with specific past geo-climatic conditions in the flowering plant species&nbsp;<em>Arabidopsis thaliana</em>. To this end, the candidate will date precisely the tens of thousands of transposition events that have occurred in&nbsp;<em>A. thaliana</em>&nbsp;over the past 100,000 years and that have been identified using machine learning algorithms in an extensive collection of genome sequences of accessions taken from across the globe. Correlations between transposition bursts and past environmental conditions will then serve to develop mathematical models aimed at predicting the effect of ongoing global warming on TE mobilization and the potential consequences on fitness</p><p>&nbsp;</p><p><strong>The candidate</strong>: We are seeking a highly motivated person, with a strong background in population genetics. Experience in genomics and programming is a plus.</p><p>&nbsp;</p><p><strong>The position</strong>: This position is fully supported by a CNRS grant, starting by October 2018. The gross monthly salary will be between 2600 and 3600 euros, depending on qualifications and experience. The contract is for one year, renewable once.</p><p>&nbsp;</p><p><strong>The application:</strong>&nbsp;Applicants should send a CV and a cover letter summarizing their past experience and motivation to Dr. Leandro Quadrana (<a href="mailto:quadrana@biologie.ens.fr">quadrana@biologie.ens.fr</a&gt;). They should also arrange to have a least two letters of reference sent to this address.</p><p>&nbsp;</p><p><strong>References:</strong></p><p>[1] Quadrana L, Colot V. Plant Transgenerational Epigenetics (2016)&nbsp;<strong><em>Annu Rev Genet</em></strong>. 2016 50, 467-491</p><p>[2] Quadrana L, Silveira AB, Mayhew GF, LeBlanc C, Martienssen RA, Jeddeloh JA, and Colot V (2016) The Arabidopsis thaliana mobilome and its impact at the species level.&nbsp;<strong><em>eLife</em></strong>&nbsp;vol. 5 pp. 1&ndash;25</p><div>&nbsp;</div><br/>
Laboratoire: Genome dynamics and epigenetic variation (GDEV)