Evolution moléculaire

Evolution of photosynthetic functions and Genome dynamics

Nom complet (en toutes lettres)
Evolution of photosynthetic functions and Genome dynamics - Laboratoire Biologie du Chloroplaste et Perception de la Lumière chez les Microalgues - UMR7141 CNRS SU
Adresse

75005 Paris
France

SFBI
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SMILE

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Stochastic Models for the Inference of Life Evolution
Adresse

Stochastic Models for the Inference of Life Evolution
CIRB - Collège de France
11 place Marcelin Berthelot

75005 Paris

France

Téléphone
+33144271391
SFBI
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GSI

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Génomique des Systèmes Intégrés
Adresse

Universite Paul Sabatier
CNRS-Laboratoire de Microbiologie et Genetique Moleculaires
BAT. IBCG
118, route de Narbonne

31062 Toulouse CEDEX 9, France  
France

Description (English)

Systematic sequencing genome projects generate large amounts of data that must be annotated for their biological exploitation. If the first annotation step may allow the identification of single genes/gene products, a complementary level of annotation consists in taking into account interactions of the proteins involved in the same supra-molecular system and/or biological process. These interactions can be stable, or transient, and either physical or functional. The cellular functions that emerge from these complex systems are not only an addition of the individual protein properties but result also from the interactions between the proteins. Biological systems result also from a complex evolutionary history, in a sense that partners and/or relationships between them can have been added, removed or replaced along the evolutionary history, with two extreme consequences, the loss or the duplication of systems in a phylogenetic clade. In general, duplicated systems do not conserve the same cellular function. Such a complex evolutionary scenario occurs when partners are encoded by multigenic families. In this framework, our group has focused its activity on two main research axes: i) development of strategies in order to identify, reconstruct and classify, from the genomic sequences, functional supra-molecular assemblies whose members belong to multigenic families and ii) phylogenomics analyses involving also the development of approaches to identify orthologous genes/proteins. ABC systems were initially chosen as a model because they form one of the largest ubiquitous families of paralogous systems that have arisen early in evolution and are involved in many essential physiological processes. The developed strategies lead to the creation and maintenance of a public database dedicated to ABC systems (ABCdb). Since then, we have extended our expertise in phylogenomics analyses on different gene families and systems through collaborations. To address the dynamics of the interaction between biological entities, we started to implement systems biology approaches focused on the modeling of the regulatory pathway of natural genetic transformation in streptococcal species.

English keywords
Integrated systems, Comparative genomics, Phylogenomics, Bioinformatics, Database, Regularory network modeling
SFBI
Membre de la SFBI

GEPV-bioinfo

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Plateau Bioinformatique de l'EEP
Adresse

Unité Evo-Eco-Paléo (EEP) - UMR 8198
CNRS / Université de Lille - Sciences et Technologies
Bâtiment SN2 bureau 116

59655 Villeneuve d'Ascq - FRANCE
France

Téléphone
33 (0)3 20 33 62 45
SFBI
N'est pas membre de la SFBI

GDEC

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Génétique, Diversité et Ecophysiologie des Céréales
Adresse

France

Téléphone
+33 (0)4 73 62 43 21
Fax
+33 (0)4 73 62 44 53
Description (English)

GDEC Team involved in Bioinformatics

English keywords
Genetic & physical & transcriptomic mapping,positional clonage,genetic recombination,genome sequencing,structural and functional annotation,workflow TriAnnot, wheat, Triticum aestivum
SFBI
Membre de la SFBI

GEB

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Genome, Evolution et Bioinformatique
Adresse

Laboratoire de Chimie Bacterienne (LCB)
UMR 7283 AMU CNRS
31 Chemin Joseph Aiguier

13009 Marseille
France

English keywords
Comparative genomics, molecular evolution, bioinformatics
SFBI
Membre de la SFBI

ESF-RCPG

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Evolution, Structure et Fonction des RCPG
Adresse

Laboratoire MITOVASC
UMR CNRS 6214 - INSERM 1083
3 rue Roger Amsler

49100 ANGERS

France

Téléphone
0244688262
SFBI
Membre de la SFBI