Biologie des systèmes

Dyliss

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
DYnamics, Logics and Inference for biological Systems and Sequences
Adresse

IRISA & INRIA Rennes
Bat 12A
Campus de Beaulieu

35042 Rennes cedex
France

Téléphone
0299847100
Description (English)

Dyliss is a research team in bioinformatics. We focus on sequence analysis and systems biology. We use qualitative formal systems to characterize genetic actors from non model species, such as algae or mining baceria, that control phenotypic answers when challenged by their environment.

  • Methods: constraint logic programming, symbolic dynamics, machine learning, formal systems.
  • Expertise: functional characterization, non-model species, multi-scale integration.
  • Application domains: marine biology, micro-environmental biology...

The main computational challenge is to face lacks and incompleteness in both expert knowledge and experimental observations. Our strategy relies on three main points.

  • We focus on a targeted functional characterization rather than on a complete understanding of the species.
  • We rely on knowledge rather than on amounts of experimentations.
  • We use model-species to validate methods.

We use qualitative formal systems for knowledge acquisition and integration. All our methods aim at identifying the space of all models that are consistent with both knowledge and observations. Then we provide tools to navigate in this space in order to investigate which properties are shared by a large proportion of the space.

SFBI
Membre de la SFBI

ComBi

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Combinatoire et bioinformatique
Adresse

Laboratoire des Sciences du Numérique de Nantes (LS2N CNRS UMR6004)
2, rue de la Houssinière

44322 Nantes
France

Description (English)

The ComBi team at LINA aims at developping original algorithmic and mathematics methods for studying problems issued from biology. Its main research topics focus on comparative genomics and systems biology.

English keywords
Comparative genomics, systems biology
SFBI
Membre de la SFBI

SBDM

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Systems Biology of Decision Making
Adresse

Laboratory of Biology and Modeling of the Cell
UMR5239
Ecole Normale Supérieure de LYON
Site Jacques Monod, Bâtiment LR3.
46 allée d’Italie -

69354 LYON cedex 07
France

Description (English)

The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.

For this we abide by the following view : "The stem-cell signature should therefore be determined by systems-biology tools that can identify patterns, rather than by the analysis of individual genes or even multiple gene-product behaviours." Zipori, D. (2004) The nature of stem cells : state rather than entity. Nat. Rev. Genet., 5, 873-878.

SFBI
Membre de la SFBI