48 mois/4 ans

Tackling the genomic dark matter through system engineering of ncRNAs in yeast

Non-coding RNAs (ncRNAs) are thought as of genomic "dark matter" for which the biological significance has been largely underestimated. A bulk of recent literature has showed how some ncRNAs are important players in cellular regulation and fitness. Rapid advances in DNA synthesis techniques have now made it possible to chemically synthesize and modify biochemical pathways and reconstruct genomes. The world’s first designer genome has been recently synthesized by an international consortium of scientists within the framework of the synthetic yeast Sc2.0 project (1, 2).

Machine learning to integrate genome, transcriptome and patient outcome in neurological disease

Project outline:

Work to decode the genetics of a devastating neurological disease. You will focus on the analysis of non-coding DNA variants and the implementation of novel machine learning algorithms to predict biological impact based on patient DNA sequence and multi-omic profiling of human postmortem tissue and stem cell models.

Computational biologist in epigenetics - Poste pourvu

Post-doctoral/engineer computational biologist in epigenetics at Nuclear Organisation and Oncogenesis Lab on the Institut Pasteur

A computational biologist position is available in the Dejean Laboratory, Nuclear Organisation and Oncogenesis Unit, to study to study the role of SUMOylation in the epigenetic mechanisms governing cellular identity in normal and disease cells.

Application manager

Lixoft (www.lixoft.com) sells advanced software applications for the modelling and simulation of drug development and clinical trials. The Lixoft products are rapidly turning into standards for the pharmaceutical industry. Our technologies are based on a seven years research program on biostatistics and modelling led by the Inria institute, still a close partner of Lixoft.

EU-ITN project manager in protein design for synthetic biology

<div>&nbsp;</div><div>The Vrije Universiteit Brussel (VUB) seeks a full-time project manager for the administration and organisation of the EU funded Marie Sklodowska-Curie Innovative Training Network RNAct &ldquo;Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics&rdquo;&nbsp;</div><div>&nbsp;</div><div>The research and training network unites 7 European laboratories and companies, and will train 10 PhD students that will combine computational and experimental approaches with the aim to design R

Postdoc Position: Bioinformatics of Long Noncoding RNA Functional Elements

<p><strong>The &ldquo;Genomics of Long Non-Coding RNAs in Disease&rdquo; Laboratory (GOLD Lab) at the University of Bern has an opportunity for a <u>Bioinformatics Postdoc</u>.</strong></p><p><strong>The Project:</strong> Understanding how long noncoding RNA (lncRNA) functions are encoded in their sequence is a great challenge in biology. Our goal is to discover, classify and characterise lncRNA functional elements by means of an integrative bioinformatic / experimental approach.

Post-doctoral position at CRCM (Campus of Luminy, Marseille France) in the field of bioinformatics applied to Pancreatic Cancer personalized therapy.

<p>Post-doctoral position at CRCM (Campus of Luminy, Marseille France) in the field of bioinformatics applied to Pancreatic Cancer personalized therapy.</p><p>A postdoctoral fellowship for 4 years is available from January 2019 at the Cancer Research Center of Marseille in the team of Nelson DUSETTI (translational medicine group, Pancreatic Cancer, INSERM U.1068) as part of the program &quot;Personalized Medicine in Pancreatic Cancer&quot; funded by The French National Cancer Institute (Inca).</p><p>This multidisciplinary project aims to propose new the

Computational Genetics

<p>The Department of Medical Biochemistry and Microbiology at Uppsala University seeks a PhD student candidate in Computational Genetics in the research group of Örjan Carlborg. The selected candidate will be offered a full time four year employment at Uppsala University. The position comes with salary and full benefits of being a Swedish University employee.