Autre

IMGT®

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
IMGT®, the international ImMunoGeneTics information system®
Adresse

34396 MONTPELLIER cedex 5 FRANCE
France

Téléphone
33(0)434359965
Fax
33(0)434359901
Description (English)

IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org, is the global reference in immunogenetics and immunoinformatics, created in 1989 by Marie-Paule Lefranc (Université Montpellier 2 and CNRS). IMGT® is a high-quality integrated knowledge resource specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) of human and other vertebrate species, and in the immunoglobulin superfamily (IgSF), MH superfamily (MhSF) and related proteins of the immune system (RPI) of vertebrates and invertebrates. IMGT® provides a common access to sequence, genome and structure Immunogenetics data, based on the concepts of IMGT-ONTOLOGY and on the IMGT Scientific chart rules. IMGT® works in close collaboration with EBI (Europe), DDBJ (Japan) and NCBI (USA). IMGT® consists of sequence databases, genome database, structure database, and monoclonal antibodies database, Web resources and interactive tools.

English keywords
immunogenetics, immunoinformatics, IMGT-ONTOLOGY, antibody, T cell receptor, IMGT Collier de Perles, major histocompatibility
SFBI
Membre de la SFBI

GSI

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Génomique des Systèmes Intégrés
Adresse

Universite Paul Sabatier
CNRS-Laboratoire de Microbiologie et Genetique Moleculaires
BAT. IBCG
118, route de Narbonne

31062 Toulouse CEDEX 9, France  
France

Description (English)

Systematic sequencing genome projects generate large amounts of data that must be annotated for their biological exploitation. If the first annotation step may allow the identification of single genes/gene products, a complementary level of annotation consists in taking into account interactions of the proteins involved in the same supra-molecular system and/or biological process. These interactions can be stable, or transient, and either physical or functional. The cellular functions that emerge from these complex systems are not only an addition of the individual protein properties but result also from the interactions between the proteins. Biological systems result also from a complex evolutionary history, in a sense that partners and/or relationships between them can have been added, removed or replaced along the evolutionary history, with two extreme consequences, the loss or the duplication of systems in a phylogenetic clade. In general, duplicated systems do not conserve the same cellular function. Such a complex evolutionary scenario occurs when partners are encoded by multigenic families. In this framework, our group has focused its activity on two main research axes: i) development of strategies in order to identify, reconstruct and classify, from the genomic sequences, functional supra-molecular assemblies whose members belong to multigenic families and ii) phylogenomics analyses involving also the development of approaches to identify orthologous genes/proteins. ABC systems were initially chosen as a model because they form one of the largest ubiquitous families of paralogous systems that have arisen early in evolution and are involved in many essential physiological processes. The developed strategies lead to the creation and maintenance of a public database dedicated to ABC systems (ABCdb). Since then, we have extended our expertise in phylogenomics analyses on different gene families and systems through collaborations. To address the dynamics of the interaction between biological entities, we started to implement systems biology approaches focused on the modeling of the regulatory pathway of natural genetic transformation in streptococcal species.

English keywords
Integrated systems, Comparative genomics, Phylogenomics, Bioinformatics, Database, Regularory network modeling
SFBI
Membre de la SFBI

TIBS

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Traitement de l'information en Biologie Santé
Adresse

France

English keywords
Sequence algorithmics, NGS, Exome
SFBI
Membre de la SFBI

G2IM

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Génomique Intégrée des Interactions Microbiennes
Adresse

Bât. Biologie A
Campus Universitaire des Cézeaux
24, avenue des Landais

63177 AUBIERE

France

Description (English)

Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tableau Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} The research projects of UMR LMGE deal with microbial prokaryotes (Achaea, Bacteria), eukaryotes (protists, microscopic fungi), and viruses, studied from molecular and cellular aspects towards their functional roles in natural ecosystems. The specificity of the laboratory is to associate competences from genomic and postgenomic on one side, and of population and ecosystem biology and ecology, on the other side. The application domains of these works are related to the environment and to the human and animal health. The general scientific strategy consists (i) to move closer genome and environment in order to favour the development of molecular ecology, and (ii) to develop interdisciplinary approaches towards the integrated knowledge of complex systems, mainly through the implementation of high-throughput tools.

English keywords
Microbial genomics, Microbial ecology, Biodiversity, Metagenomics, Genome annotation, DNA microarrays (phylogenetic, functional), Bioremediation, metabolic pathways, Pathogens
SFBI
Membre de la SFBI