Epigenomics and computational stem cell biology

Type de poste
Niveau d'étude minimal
Durée du poste
Contrat renouvelable
Contrat renouvelable
Détails de renouvellement
Renewal will depend on performance
Date de prise de fonction
Date de fin de validité de l'annonce
Nom de la structure d'accueil

25 rue du Docteur Roux
75015 Paris

Pablo Navarro
Email du/des contacts

Postdoctoral positions are available in the laboratory of Pablo Navarro at the Institut Pasteur, Paris.

We use epigenomic and transcriptomic technologies combined with imaging and genetic engineering to study how stem-cells and early mouse embryonic cells establish and maintain their identities. The goal of our ERC-funded project (BinD) is to understand how mitosis influences gene regulatory networks and how transcription factors, chromatin modifications, and mitotic regulators operate during and shortly after cell division. Our work relies heavily on the use of computational and statistical approaches to dissect how gene regulatory information is conveyed through mitosis. Recent examples of our work in this area are:

Genome Res. 2019 Feb;29(2):250-260. doi: 10.1101/gr.243048.118.

Elife. 2019 Oct 10;8:e47898. doi: 10.7554/eLife.47898.

The specific questions that will be addressed will strongly depend on the selected candidate, who will benefit of a large degree of freedom. A doctoral degree (Ph.D) in life or computational sciences is required, as is an expertise in NGS analysis - a vast amount of datasets (ChIP-seq, ATAC-seq, MNase-seq, Hi-C, RNA-seq) are already available. Candidates with both experimental and computational skills will be favored although this does not represent an essential aspect. They must be collegial, passionate and show a strong scientific drive and curiosity.

The Institut Pasteur offers an outstanding environment for life sciences training in a wide range of disciplines, including a large center dedicated to computational biology. There are ample opportunities for interactions and collaborations within Pasteur and more generally with other institutions of the Parisian area, where a vibrant community works on Epigenetics.

A cover letter, CV, and the names and contact information for three references should be emailed to Pablo Navarro (pnavarro@pasteur.fr)

Equipe adhérente personne morale SFBI
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