2 Rue Angélique Ducoudray
Université de Bourgogne, Bâtiment B3
Epigenetic effects of Assisted Reproductive Technologies
Millions of children have been born worldwide via assisted reproductive technologies (ART). Yet, the safety of these techniques is not fully demonstrated. ART are associated with numerous complications, including imprinting disorders, likely because ART coincide with epigenetic reprogramming events. Animal experiments have revealed that ART can impact epigenetic regulation of key developmental genes. However, knowledge about this phenomenon is lacking in humans.
The projects aim to study the interactions between the human embryo and the in vitro “milieu” and their consequences on the epigenetic regulation of imprinted genes, transposable elements and the genome in toto, through three important times of development (preimplantation, birth, and childhood) and thanks to adaptive tools such as high-throughput technologies dedicated to small numbers of cells (PBAT and scRNA-seq) for human embryo research.
Our new group has questions on epigenetics of human reproduction which have profound implications for the ART field. Our group is part of the Team “Genetics of development disorders” which studies genes and molecular mechanisms responsible for genetic diseases linked to developmental abnormalities. The team has developed strong expertise in genetic studies using genome-wide technologies such as whole-exome sequencing.
We are part of the « Centre for Translational and Molecular medicine », INSERM UMR1231, located in Dijon, one of the largest research centres in Burgundy university which consists of 9 research teams and and 10 state-of-the-art core facilities. The group, host team and research centre, will provide a dynamic and interactive environment.
The research center and fruitful collaboration with D. Bourc’his (Curie Institute, Paris) represent an environment of choice to develop these projects as they benefit from equipment and tools to speed up to achieve different objectives.
We invite applications from highly motivated and qualified individuals - excellent knowledge of bioinformatics and statistical tools are essential as well as experience with NGS analyses (genomics or transcriptomics).
- Pretreatment of NGS data via pipelines dedicated to DNAseq, RNAseq scRNAseq data and microarray data (EPIC-array)
- Statistical analysis of generated data
- Advice and expertise in bioinformatics/biostatistics for biologists/clinicians in the team
Required skills :
- Solid training on bioinformatics/biostatistics
- Strong working knowledge of bioinformatics tools dedicated to the analysis of NGS data
- Strong working knowledge of Linux, R, python, perl
- Knowledge in genetics and molecular biology
- Mastery of English (spoken and written)
- Research expertise attested by a track record of research/academic achievement and publications in internationally recognized peer-reviewed journals
- Good communication and team spirit
- Know to work independently and integrate into a multidisciplinary team
- Master 2 degree in bioinformatics or equivalent
Type: CDD as bioinformatician/biostatistician
Début/Beginning: November 2020
Durée du contrat/Length of contract: 16 months
Structure employeur/organization: INSERM UNIVERSITE
Applicants should send their CV (including publication record), letter of motivation and name of 2 references to Patricia Fauque.
Email : email@example.com