U1287 - INSTITUT GUSTAVE ROUSSY - Pavillon de recherche 1
114 rue Edouard Vaillant
The position is funded by the Agence Nationale de la Recherche for a period of 3 years and is available as soon as possible.
The aim of the project is to identify the epigenetic mechanisms that control the expression of transposable elements in hematopoietic stem cells, the impact of the derepression of these sequences on the transcriptome, in leukemic development and resistance to treatment.
We are working on RNA-seq and ChIP-seq data performed on hematopoietic stem cells isolated from mice that were submitted to stresses inducing a premature aging, from mice models of chronic myelomonocytic leukemia (CMML), a myeloid hemopathy typically associated with aging, and on human primary cells from healthy elderly subjects and CMML patients.
The candidate will be involved in the analysis of all the data generated in the group from RNA-seq and ChIP-seq experiments. He/she will work on multiple mapping reads for the identification of transposable elements, and set-up the analysis for identification of chimeric transcripts (between a retroelement and a gene), and identification of alternative splicing events.
Experience in biology : hematology, immunology, stem cells, or transposable retroelements would be a plus.