146 rue Léo Saignat
The Bordeaux Population Health (BPH) Research Center, from the University of Bordeaux and the National Institute of Health and Medical Research (Inserm) offers a 2-year (renewable) position for a post-doctoral researcher in genetic epidemiology / statistical genetics to work on deciphering the genetic, epigenetic, and molecular signature of cerebral small vessel disease (cSVD) across the lifespan. The candidate will work under the supervision of Prof. Stéphanie Debette (professor of epidemiology and neurology) and in close collaboration with Prof. Fumihiko Matsuda (visiting professor at the BPH and director of the Kyoto University Centre for Genomic Medicine), Dr. Aniket Mishra (statistical geneticist at the BPH), and Dr. David-Alexandre Tregouët (Inserm research director in statistical genetics).
The project will include: (i) identifying rare variants, or burden of rare variants associated with MRI-markers of cSVD using extensive next generation sequencing data (mostly whole genome) available in the 3C and i-Share cohorts (France) and the Nagahama cohort (Japan); transethnic fine-mapping to be implemented; (ii) exploiting cutting-edge methyl-C sequencing data to analyze epigenetic determinants of cSVD across the lifespan and derive methylation quantitative trait loci to functionally explore cSVD genomic risk loci.
Opportunities will be available to expand this work to other molecular biomarkers (metabolomics, proteomic) in the process of being generated.
This position is linked to the ERC project SEGWAY on environmental and genome-wide predictors of early structural brain alterations in young students and the Investment for the Future RHU grant SHIVA on covert cerebral small vessel disease and dementia (PI S Debette).
The candidate will benefit from close interactions with:
- Other RHU-SHIVA partners with expertise in biostatistics, epidemiology, brain imaging, experimental models of vascular disease, clinical neurology; SHIVA/SEGWAY collaborators (McGill Genome Center)
- International consortia that the team collaborates closely with: mainly the Cohorts of Heart and Aging Research in Genomic Epidemiology consortium (CHARGE, www.chargeconsortium.com) and the International Stroke Genetics Consortium (ISGC, www.strokegenetics.org)
EXPERIENCE, KNOWLEDGE, SKILLS & SELECTION CRITERIA
Highly motivated, enthusiastic applicants that hold a Ph.D. degree in Statistical genetics, Genetic Epidemiology, Biostatistics or related fields
Experience and theoretical knowledge in complex disease genomics, ideally with prior experience in working with next generation sequencing data
Flexibility and interest in expanding knowledge and applications to other fields of molecular epidemiology
Excellent programming skills in R and if possible other programming languages
Experience with drafting high-quality manuscripts
Fluent in spoken and written English (French language is not a requirement)
Environment: Bordeaux is located in the South-West of France, at 2 hours distance from Paris by train, ranking #1 in quality of life in France. Bordeaux University offers excellent facilities, a highly dynamic environment with multiple international partnerships and initiatives, and practical support for international researchers.
Working conditions: Compliance with French legislation and regulations under a full-time contract. Employees receive the benefits of the French Social Security (health insurance) system.
Training and Career: Postdoctoral researchers joining the BPH centre gain access to the Univ. Bordeaux advanced research training and career development opportunities, all within in a competitive international environment. Courses, seminars and workshops on themes of particular interest to postdocs are offered regularly by the BPH and the University of Bordeaux (e.g. digital public health graduate program)
Applications for the above opening should include a CV, motivation letter and contact information of potential referees and should be sent by e-mail to: email@example.com.