94805 Villejuif Cedex - France
69621 Villeurbanne cedex
Research at BF2I is focused on the comprehension of the functions managing the interaction of specific insect pests (aphids and weevils) with their direct biological partners (host plants and symbiotic microorganisms). Research approaches are multi-disciplinary thanks to the different expertise of the staff members.
The central theme of our research is to understand the relationships established between insects and their symbionts elucidating the molecular mechanisms that allow the establishment, maintenance and persistence of these complex interactions in multiple insect generations.
The final goal of research on these complex biological interactions, often involving multiple partners in interaction with the environment, is to identify tools and define new concepts for an integrated approach for plant protection against insect pests. Our research results are to be central for the development of agricultural practices that are sustainable, and respect both the environment and human health.
75230 Paris Cedex 05, France
We are charter member of the network « Genomic Paris Centre », in partnership with Institut Curie and Université Pierre et Marie Curie (UPMC). We are approved by the Infrastructures en Biologie Santé et Agronomie (IBiSA) and are part of the France Génomique consortium.
We offer our help in every aspect of your genomic projects. Whether you have questions about funding request, experimental design, management of your samples, use of our equipment, data analysis or training, we are here to help. Do not hesitate in visiting the website to discover our activities. You can go to the contact page if you wish to know more about us.
Laboratory of Biology and Modeling of the Cell
Ecole Normale Supérieure de LYON
Site Jacques Monod, Bâtiment LR3.
46 allée d’Italie -
69354 LYON cedex 07
The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.
For this we abide by the following view : "The stem-cell signature should therefore be determined by systems-biology tools that can identify patterns, rather than by the analysis of individual genes or even multiple gene-product behaviours." Zipori, D. (2004) The nature of stem cells : state rather than entity. Nat. Rev. Genet., 5, 873-878.