voies métaboliques

Dyliss

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
DYnamics, Logics and Inference for biological Systems and Sequences
Adresse

IRISA & INRIA Rennes
Bat 12A
Campus de Beaulieu

35042 Rennes cedex
France

Téléphone
0299847100
Description (English)

Dyliss is a research team in bioinformatics. We focus on sequence analysis and systems biology. We use qualitative formal systems to characterize genetic actors from non model species, such as algae or mining baceria, that control phenotypic answers when challenged by their environment.

  • Methods: constraint logic programming, symbolic dynamics, machine learning, formal systems.
  • Expertise: functional characterization, non-model species, multi-scale integration.
  • Application domains: marine biology, micro-environmental biology...

The main computational challenge is to face lacks and incompleteness in both expert knowledge and experimental observations. Our strategy relies on three main points.

  • We focus on a targeted functional characterization rather than on a complete understanding of the species.
  • We rely on knowledge rather than on amounts of experimentations.
  • We use model-species to validate methods.

We use qualitative formal systems for knowledge acquisition and integration. All our methods aim at identifying the space of all models that are consistent with both knowledge and observations. Then we provide tools to navigate in this space in order to investigate which properties are shared by a large proportion of the space.

SFBI
Membre de la SFBI

MEDiS

Acronyme ou nom de la structure
Nom complet (en toutes lettres)
Microbiologie Environnement Digestif Santé
Adresse

63001 CLERMONT-FERRAND
France

Description (English)

Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tableau Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} The research projects of UMR LMGE deal with microbial prokaryotes (Achaea, Bacteria), eukaryotes (protists, microscopic fungi), and viruses, studied from molecular and cellular aspects towards their functional roles in natural ecosystems. The specificity of the laboratory is to associate competences from genomic and postgenomic on one side, and of population and ecosystem biology and ecology, on the other side. The application domains of these works are related to the environment and to the human and animal health. The general scientific strategy consists (i) to move closer genome and environment in order to favour the development of molecular ecology, and (ii) to develop interdisciplinary approaches towards the integrated knowledge of complex systems, mainly through the implementation of high-throughput tools.

English keywords
Microbial genomics, Microbial ecology, Biodiversity, Metagenomics, Genome annotation, DNA microarrays (phylogenetic, functional), Bioremediation, metabolic pathways, Pathogens
SFBI
Membre de la SFBI