36 mois/3 ans

PhD in Genetic Epidemiology

Description
A 3-year PhD position is available from September 2020 at Inserm UMR1167 unit – Risk factors and molecular determinants of aging-related diseases –, which is part of the Distalz Labex. The successful candidate will work in Team 3, led by Doctor Jean-Charles Lambert. This multidisciplinary team is a world leader in genetic epidemiology of Alzheimer’s disease (AD).

Multi-omics transfer learning to extend proteomics coverage beyond mass spectrometry quantitation limits

Context: Distinct genes are expressed in different cell types and under different conditions, yielding different proteins from cell to cell. Precisely measuring the dynamics of proteins (the `atoms of life') would provide an unrivaled characterization of biological states. However, methodological obstacles currently impede robust and accurate estimation of protein abundance. On the one hand, the core technology of proteomics (namely mass spectrometry) is hampered by a complex missing data problem [1], with peptides (i.e.

RNA structure prediction, binding site detection and small-molecules virtual screening

We are seeking a candidate for a PhD position funded by a French CIFRE fellowship. The candidate will share their time between Sanofi (under the supervision of Dr. Paraskevi Gkeka) and Institut Pasteur (under the supervision of Dr. Max Bonomi in the Structural Bioinformatics Unit of the Department of Structural Biology and Chemistry) and they will be enrolled in the Doctoral School “Complexité du vivant” at Sorbonne Université, Paris.

Immuno-oncology

(See below for English)
Modélisation de l’immuno-senescence des lymphocytes T induite par le TNF et le métabolisme du céramide dans la résistance des patients atteints de mélanome aux inhibiteurs de points de contrôle immunitaire.

La thèse sera co-encadrée par le Dr. VERA PANCALDI (Computational Biologist), INSERM CRCT UMR 1037 (30%). Le candidat/e doit se presenter au concours de l'école doctorale de l'Université Paul Sabatier (Note Master 2 > 14/20 où equivalente)

Mots clefs: Cancer, Immunothérapie, Essais cliniques, Biomarqueurs, métadonnées, bioinformatique

BAYESIAN NETWORKS APPLIED TO GLOBAL EPIDEMIC SPREAD

We seek for a PhD candidate for the PhD program of the Sorbonne Center for Artificial Intelligence (SCAI). The selected candidate will be enrolled in the PhD school Pierre Luis of Public Health to work within a collaboration between the Team ‘Communicable Diseases Surveillance and Modelling’ of the Pierre Louis Institute of Epidemiology and Public Health (INSERM) and the Team ‘Statistics, data and Algorithm’ of the Laboratory of Probability, Statistics and Modelling (CNRS).

Rôle des éléments transposables dans l’histoire évolutive des gènes dupliqués chez les drosophiles

Nous proposons un sujet de thèse dans le domaine de la bioinformatique évolutive à l'Université de Lyon au sein de l’UMR 5558 LBBE sous la direction de Emmanuelle Lerat et Carène Rizzon (LaMME, Université Evry).

Le financement proposé est via le concours de l'école doctorale E2M2 à laquelle le LBBE est rattaché.