IBDM UMR 7288

M2 - Development of a pipeline for NGS -omics data integration

• Description:
During tissue formation, transcriptional programs are deployed in a specific temporal order to ensure that progenitor cells first amplify and then differentiate to generate the functional cells of a mature organ. In principle, epigenetic marks on chromatin are used to limit the repertoire of genes that can possibly be dynamically regulated at a given time, ensuring robustness in transcriptional dynamics. However, the mechanisms that determine when and at which genes these epigenetic marks have to be deposited are unclear.