Doctorat

Thèse

Responsable de la Plateforme de Séquençage de l’Institut de Biologie Intégrative de la Cellule, Gif-sur-Yvette

Ouverture du poste au concours externe CNRS

Emploi-type : Ingénieur-e en calcul scientifique
Affectation : Institut de Biologie Intégrative de la Cellule, GIF SUR YVETTE
Groupe de fonction : Groupe 2

Mission
L'ingénieur-e expert-e en calcul scientifique sera responsable scientifique de la plateforme de séquençage de l'I2BC. Il/elle dirigera le groupe de bio-informatique et conduira le développement de nouveaux outils permettant d'améliorer le traitement des projets.

Notation and ranking of subgraphs extracted from biological knowledge graphs

The post-doctoral project concerns the analysis of complex interaction networks. The main ressource at our disposal is a huge heterogeneous graph database (provided by EdgeLeap for the FIGHT-HF program) that represents various types of interactions between various groups of elements : proteins, diseases, drugs, etc. One objective of the FIGHT-HF project is to exploit this ressource to identify new biomarkers characteristics of certain heart-failure mechanisms.

biochimie / ingénieries des protéines

Position description – A 2-year post-doctoral research position (with a possible extension of
1 year), is available in the group of V. Lattard “Resistance to vitamin K antagonists” at the
RS2GP Laboratory, in VetAgro Sup, Lyon, France. Our research focuses on the molecular
mechanisms that underly resistance to vitamin K antagonists used in human medicine as
antithrombotic drugs or in rodents as rodenticides. Vitamin K antagonists inhibits specifically
the Vitamin K epoxide reductase (VKORC1) enzyme involved in the vitamin K cycle. Numerous

Post-doctoral fellow in method development for Structural Variation detection

A 2-year post-doctoral fellowship is available at the Inria Genscale team in Rennes (France) to work on the development of novel computational methods for the detection and analysis of structural variations with linked-read sequencing data with Dr Claire Lemaitre and colleagues (http://people.rennes.inria.fr/Claire.Lemaitre/).

Computational pathology

The possibility of combining imaging modalities with gene and protein-level data opens new avenues for the development of novel biomarkers or for the identification of image-based surrogate biomarkers for gene/protein signatures. The current methods in computational pathology are, however, still under-developed for fully exploring this domain. We are looking for a strong postdoctoral candidate with proven research record in biomedical imaging – preferably pathology image analysis – to develop new approaches to computational pathology.