Mots-Clés

ARNs long non codants, Sepsis, Réponse thérapeutique, Corticoides, Biomarqueurs, Nouveaux transcrits

Description

LONG NON CODING RNAS IN CORTICOID RESPONSE DURING SEPSIS

Sepsis, notably including the most severe forms of COVID-19, is a highly prevalent cause of death worldwide and a public health issue according to WHO. Corticosteroids (CS) are a proven low-cost treatment of sepsis. The therapeutic response to CS, however, is heterogeneous. We recently identified both known genes and novel long non-coding transcripts associated with CS response in a study of 50 critically-ill COVID-19 patients. These results are being validated using a replication cohort.

Our working hypothesis is that some of these novel transcripts might decisively impact the course of sepsis and the patients’ therapeutic response to CS. Consequently, the thesis aims are to select the most relevant transcripts (based on differential expression, tissue and disease specificity, coregulation with relevant protein-coding genes, phylogenetic conservation), to assess their potential usefulness as diagnostic or prognostic biomarkers as well as to anticipate the individual patient’s CS response and finally, to characterize them at the genomic level and also functionnally using cellular models.