Consequences of a recurrent mutation of the PU.1/SPI1 in human lymphoproliferative disorder
CDD · IE · 36 mois Bac+5 / Master U1170 · Villejuif (France)
Date de prise de poste : 1 juin 2021
RNA-seq single-cell ChIP-seq
U1170 is working in the field of hematological malignancies is seeking a motivated bioinformatician. A 3-year contract managed by INSERM is available to fill a position that can be fitted to the candidate's experience and her/his expectations. She/he will be imbedded in U1170 with interactions with the local bioinformatics community.
The successful candidate will participate to a project investigating the consequences of a recurrent mutation of the PU.1/SPI1, a member of the ETS family of transcription factor, identified in a human lymphoproliferative disorder. A conditional model of expression of this mutation in mice leads to abnormalities in germ center response and plasma cell differentiation.
The project will use transcription (RNA-seq and single-cell RNA-seq), ChIP-seq data generated in the team and available in the databases to identify the mechanisms underlying the observed abnormalities in B lymphocyte maturation. The observations will be functionally validated in cell lines and model organisms, and verified using data from human lymphoproliferative and lymphoma samples.
To apply or to ask for more information, please send an email to Olivier.BERNARD@gustaveroussy.fr
Date limite : 31 mai 2021
Offre publiée le 20 avril 2021, affichage jusqu'au 31 mai 2021