Mots-Clés

NGS RNA-seq ChIP-seq Hi-C single cells

Description

• The Curie institute

The Institut Curie is a major player in cancer research and the fight against cancer. It consists of a hospital and a Research Center with more than 1000 employees with strong international representation. The objective of the Institut Curie Research Center is to develop fundamental research and use the produced knowledge to improve the diagnosis, prognosis, and therapy of cancers within the framework of a continuum between fundamental research and innovation, at the service of patients.

• The “Diversity and Plasticity of Childhood Cancer”research group

This group headed by Olivier Delattre investigates the role of genetic alterations in the development of childhood cancers with a specific focus on their impact on gene regulation and cell plasticity (https://science.institut-curie.org/team-delattre/). Some recent publications of the group: Surdez et al, Cancer Cell, 2021; Aynaud et al, Cell Reports, 2020; Boeva et al, Nat Genet, 2017; Grunewald et al, Nat Genet, 2015.

• Main missions

- Use a variety of NGS-based (RNA-seq, ChIP-seq, Hi-C …) approaches to identify key transcriptional regulators, decipher core regulatory circuitries and 3D genome structure in malignant cells.

- Use and develop single cell approaches to investigate cell diversity, tumor heterogeneity and plasticity. - Integrate multi-omic data

- Perform appropriate statistical analyses

- Collaborate with biologists in the group and with the core bioinformatic unit (U900) of the institute.

• Profile of the candidate

- PhD, Grandes Ecoles diploma or similar experience

- Strong background in bioinformatics and computational biology

- Experience of working in a Unix environment and of using R and other language (Perl, Python….)

- Experience in NGS and single cell data analysis

- Knowledge in cancer genetics and cell biology

- Good level in English

• How to apply?

Send CV, motivation letter and recommendation letters (or addresses) from 3 referees to Dr Olivier Delattre at olivier.delattre@curie.fr before June 15th.