Mots-Clés

oncoimmunology, gene regulation, genetic variants

Description

Tumorigenesis is controlled by immunosurveillance mechanisms implemented by cytotoxic innate and adaptive immune cells (PMID 30275043). On the other hand, many cancers such as lung and breast cancer show germinal genetic components driving susceptibility (PMID 28615365). Many frequent genetic variants fall in non-coding regions and are likely gene regulatory variants (PMID: 31045203). We are analysing the regulatory regions and variants of immune system cells, particularly those involved in cancer protection. In this internship, we want to look for frequent regulatory variants common to the immune system and cancers. To achieve this aim, the student will contribute to our ongoing analyses that include statistical genetics and machine learning analysis of gene regulatory sequences and variants (DOI:10.1101/2020.01.29.924266 , PMID:29912365).