M2 internship: Analysis of gene regulatory variants of the immune system involved in cancer
Stage · Stage M2 · 6 mois Bac+4 INSERM TAGC 1090 · Marseille (France)
oncoimmunology, gene regulation, genetic variants
Tumorigenesis is controlled by immunosurveillance mechanisms implemented by cytotoxic innate and adaptive immune cells (PMID 30275043). On the other hand, many cancers such as lung and breast cancer show germinal genetic components driving susceptibility (PMID 28615365). Many frequent genetic variants fall in non-coding regions and are likely gene regulatory variants (PMID: 31045203). We are analysing the regulatory regions and variants of immune system cells, particularly those involved in cancer protection. In this internship, we want to look for frequent regulatory variants common to the immune system and cancers. To achieve this aim, the student will contribute to our ongoing analyses that include statistical genetics and machine learning analysis of gene regulatory sequences and variants (DOI:10.1101/2020.01.29.924266 , PMID:29912365).
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Date limite : 1 janvier 2022
Offre publiée le 7 août 2021, affichage jusqu'au 1 janvier 2022