Mots-Clés

Omics developer R&D

Description

Company presentation :

Signia Therapeutics is an innovative French start-up proposing a breakthrough strategy to identify molecule candidates rapidly and efficiently for a specific therapeutic indication. Molecule can be already marketed, shelved drugs from the pharma industry or proprietary molecules. We are currently focusing our development on respiratory disease and more specifically infections.

The SIGNATURA platform strategy is based on a 2-step process: (i) In silico prediction of candidate from the comparison of transcriptomic signatures of clinical samples from infected patients or physiologically relevant ex vivo model of infections against a proprietary data bank of molecule-specific signature on the same model. (ii) Pre-clinical validation of the therapeutic effect using an ex vivo model of reconstituted epithelium at the air-liquid interface along with in vivo testing in small animals.

Within the company, the data science R&D team mission is (i) to implement state of the art tools in the field to predict best candidates and MoA (Mode of Action); (ii) to create innovative tools and IA to increase the predictive power of the plateform; (iii) to maintain the infrastructure allowing data storage and data analysis and (iv) to lead the predictive analysis and support the preclinical team for investigations.

Job description:

Signia Therapeutics is looking for a new bioinformatic developer attached to the R&D data science team.

Your missions will be the following:

• Large-scale data mining of Omics available on public database.
• Implementation and development of methods for:
• (i) data integration and normalization methods
• (ii) data mining for non-expression Omics (e.g., Interactomics).
• (iii) multi-Omics data integration (alongside functional data).
• (iv) the comparison of Omics signatures.
• Interact with biologist to perform in-depth and personalized analyses to answer complex questions

Your missions will be the following:

• Support and guidance to the other members of the R&D team.
• Pipeline automation- Unit and integration test - CI/CD - Functional tests
• IT infrastructure management

Profile description:

Your education level is equivalent or higher to a master’s degree (MsC) ideally with at least 3 years of experience.

Required skills:

• Programming language: Python or R (C/C++ is a plus)
• IT environnement : Linux CLI
• Knowledge: Omics, Systems Biology, Bioinformatics database, Statistics, Algorithmics, Graphs

Bonus skills:

• IT environnement: Docker, Gitlab, Slurm, Openstack, DevOps
• Pipeline framework: At least one and preferably CWL
• Data visualization R or python plot library. Shiny (rstudio) project development