Mots-Clés

Transcription factor gene expression

Description

Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors to regulatory regions through the recognition of specific DNA sequence motifs. Additionally, the physical access of transcription factors to DNA can be modulated by epigenetic regulation, such as DNA methylation, nucleosome positioning and histone modifications. Failure to maintain this tight regulation of gene expression results in developmental defects and various diseases including cancer. During this internship, you will integrate single-cell RNA-seq data and transcription factor motifs to study how transcription factors regulate gene expression. You will work in the international team of Nacho Molina under the supervision of Anaïs Bardet and will benefit from our strong expertise in computational biology for the success of the project.

We are looking for a student with a bioinformatics background with experience working in a linux environment, a good level in a scripting language (e.g. bash, puthon, perl) and R as well as data analysis methods and statistics, a good knowledge of biology and interest in genomic and gene regulation, the ability to work in a team with both computational and experimental biologists and a good level of spoken and written english.