Mots-Clés

molecular modeling, docking, virtual screening, fragment-based drug design, molecular dynamics

Description

An open post-doctoral position in the Structural Bioinformatic & Chemoinformatic team (SB&C) at the ICOA research center of the University of Orléans (France).

The ICOA (Institute of Organic and Analytical Chemistry), located in the heart of the campus of the University of Orléans, gathers more that 120 persons, including researchers, post-doctoral researchers, PhD students, engineers, technicians, and administrative staff. Activities of the research center are focused on the chemical sciences of bioactive molecules. The main objective of our research activities is to discover novel bioactive molecules having potential applications as drugs, imaging/mechanistic probes or as components of cosmetic formulations.

The post-doctoral position is open in the Structural Bioinformatics and Chemoinformatics (SB&C) team led by Pr. Pascal Bonnet. The SB&C team develops and applies new in silico methods in the aim of understanding and designing molecular structures and their interactions with biomolecular entities and also to design new innovative and active compounds in the fields of therapeutic innovation, cosmetics and analytical chemistry.

The recruited post-doc will be involved in collaborative projects funded by the ANR and the LabEx IRON. Focused on structure- and fragment-based drug design, these research projects will require notably virtual screening and docking experiments and a good knowledge in protein-ligand interactions, as well as knowledges in molecular dynamics approaches. Skills in python programming language are highly recommended to facilitate the use of the tools developed in the team.

Profile requirements

• PhD in bioinformatics or chemoinformatics
• Good skills in molecular modeling and structural bioinformatics, especially in molecular docking and virtual screening
• Knowledge in molecular dynamics simulations
• Proficiency with at least one programming language (python preferably) 
• Knowledge in Linux environment
• Skills in Django development will be an asset

Please send a CV and the name of two references to pascal.bonnet@univ-orleans.fr and samia.aci-seche@univ-orleans.fr