Mots-Clés

Docking, PROTAC, molecular modelling

Description

An open post-doctoral position in the Structural Bioinformatic & Chemoinformatic team (SB&C) at the ICOA research center of the University of Orléans (France).

The ICOA (Institute of Organic and Analytical Chemistry), located in the heart of the campus of the University of Orléans, gathers more that 120 persons, including researchers, post-doctoral researchers, PhD students, engineers, technicians, and administrative staff. Activities of the research center are focused on the chemical sciences of bioactive molecules. The main objective of our research activities is to discover novel bioactive molecules having potential applications as drugs, imaging/mechanistic probes or as components of cosmetic formulations.

The post-doctoral position is open in the Structural Bioinformatics and Chemoinformatics (SB&C) team led by Pr. Pascal Bonnet. The SB&C team develops and applies new in silico methods in the aim of understanding and designing molecular structures and their interactions with biomolecular entities and also to design new innovative and active compounds in the fields of therapeutic innovation, cosmetics and analytical chemistry.

The recruited post-doc will be involved in collaborative projects funded by the CosmetoSciences program. The objective of the project is to conceive efficient PROTACs from the designed inhibitors of the chemist partner. The objective of the project is to conceive efficient PROTACs from the designed inhibitors of the chemist partner. For this purpose, an expertise in docking experiments and in protein-ligand interactions are required, as well as knowledges in molecular flexibility and in molecular dynamics approaches.

Profile requirements

• PhD in bioinformatics or chemoinformatics
• Good skills in molecular modeling and structural bioinformatics, especially in molecular docking and virtual screening
• Knowledge in molecular dynamics simulations
• Proficiency with at least one programming language (python preferably)
• Knowledge in Linux environment
• Knowledge of the MOE suite will be an asset