Mots-Clés
epigenomics
splicing
cancer
RNA-seq, ChIP-seq
CUT&Run, single-cell RNA-seq
Description
A 1.5-year position (extendable up to 3 years) is available at the “Genome Integrity, RNA and Cancer” Unit (UMR3348) at the Institut Curie in Orsay (nearby Paris in France) in the group “Chromatin & Splicing” headed by
Reini F. LUCO (
https://institut-curie.org/team/luco).
Project description:
Our team aims at deciphering the role of histone modifications and histone variants in pre-mRNA alternative splicing regulation. Alternative splicing is an RNA process in which different mature mRNAs can be obtained from the same pre-mRNA sequence, increasing like this the protein diversity and capacity of a cell to gain new phenotypic traits. In the past 20 years, chromatin has been shown to play an important role in this highly regulated process, although the mechanisms are not entirely known yet. Using available and soon to be developed genome-wide transcriptomics and epigenomics data, we are looking for splicing signatures dependent on chromatin modifications to elucidate the functional role of these marks in splicing regulation. Different human and mouse models will be used in collaboration with leaders in the chromatin, splicing and cancer fields.
Candidate requirements
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Master or PhD, preferably in Data Science, Bioinformatics or related fields.
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Solid skillset for handling NGS datasets and expertise in developing analysis pipelines, with competence for RNA-seq and ChIP-seq data manipulation.
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The candidate will need to be autonomous and resourceful with experience in programming and knowledge in biostatistics.
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Strong interest in life sciences.
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Basic knowledge in biology (namely chromatin, transcription, splicing) will be an advantage.
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Ability to collaborate with “wet bench” researchers.
Work environment
The candidate will benefit from the top-level scientific environment of Institut Curie, and of state-of-the-art technological platforms, including a supportive bioinformatics department. The lab is located in the Orsay Campus nearby the prestigious Paris-Saclay University and is in close contact with all the research teams of the Institut Curie, providing interdisciplinary expertise and a friendly and international environment. Salary will be based on initial formation and experience.
Candidature
Procédure : To apply, please send: curriculum vitae, cover letter clearly stating your motivation and future research interests/plans and the names/contact information of 2 or 3 referees to reini.luco@curie.fr
Date limite : 30 juin 2023
Contacts
Reini Luco
reNOSPAMini.luco@curie.fr
https://institut-curie.org/team/luco
