Mots-Clés

bioinformatique biologie computationnelle génomique apprentissage automatique mutabilité pathogénicité

Description

The Computational Biology and Bioinformatics group of the Brussels University (ULB) (https://3bio.polytech.ulb.be/en/bioinfo) is seeking candidates for a postdoctoral position.

Research context:

Unraveling the biophysical mechanisms that drive single nucleobase substitutions in different regions of the human genome is one of the key questions of the post-genomic era. These mutations, whether inherited or somatic, are potentially responsible for a huge range of rare and complex diseases. The rationalization of these mechanisms is highly intricate and often requires a diverse set of approaches, since base substitutions depend on the nucleotide sequence context and can be triggered by a wide range of physical, chemical or biological factors.

Objective:

The AtOme project aims to bridge the gap between the atomic-level characterization of mutagenesis processes and the resulting phenotypic traits, by using innovative multiscale computational approaches combining genomic and proteomic data with machine learning techniques. The end-goal of the project is the deployment of a novel predictor of genome mutability and of the impact of mutations on regulatory mechanisms, protein fitness and pathogenicity. The project will be carried out within a highly multi-disciplinary and enthusiastic bioinformatics team, in collaboration with molecular biologists and clinicians who are experts in complex diseases (cancer, autism).

Offer:

We are offering you a full-time postdoctoral position for 2 years, to come and work on the AtOme project in a laboratory with strong expertise in the field of bioinformatics and an attentive care to our work culture. The starting date is flexible (between now and January 2023) and there is a possibility of extension through an FNRS postdoctoral research grant or a Marie Curie EC grant.

Required:

• PhD degree in Sciences (Bioinformatics, Bioengineer, Physics, Chemistry, Informatics).
• Excellent programming skills.
• Excellent publication record.
• Maximum 6 years research experience after PhD.
• International mobility (maximum 24 months of residence in Belgium in the last 3 years).

Desirable:

Experience in machine learning and/or bioinformatics.