Mots-Clés

genomics, transcriptome, methylome, liver cancer, anti-cancer therapies

Description

Engineer in Bioinformatics/Data Analysis – 1-year fixed-term contract renewable for 2 years, Paris Cordeliers Research Center, Inserm UMRS1138 FunGeST team

POSITION SUMMARY

The team "Functional Genomics of Solid Tumors" FunGeST (Inserm UMRS1138, University of Paris, Sorbonne University), led by Professor Jessica Zucman-Rossi, is located at the Cordeliers Research Center in the 6th district of Paris and is recruiting on a fixed-term contract (12 months, renewable for a further 24 months), a Bioinformatics Engineer to perform bioinformatics analysis of genomic and biological data.

The position is available from October 2022

PRESENTATION OF DIRECTION/HOST STRUCTURE OF THE POSITION

The team "Functional Genomics of Solid Tumors, FunGeST" led by Pr Zucman-Rossi is an international leader in the field of genomics of liver, mesothelioma and virus-induced tumors. http://zucmanlab.com/

The Cordelier Research Center (CRC) has an international reputation, with 17 research teams and 4 technological platforms. The CRC's main trustees are INSERM, Sorbonne University and the University of Paris. Research projects are mainly focused on the study of mechanisms involved in cancer, immunology, metabolism and pathophysiology. https://www.crcordeliers.fr/

SUPERVISION

The engineer will work under the supervision of Sandra Rebouissou (Inserm researcher) and Jean-Charles Nault (Professor at the University of Paris Nord), scientific leaders of the projects, with the support of the CRC bioinformatics platform (Aurélien de Reyniès).

ACTIVITIES AND TASKS

Activities

• Use pre-existing bioinformatics tools and develop new ones as needed
• Understand the biological problem and the questions raised
• Provide bioinformatics advice and support to the team's biologists
• Interact with experimenters and bioinformaticians of the team and collaborating teams
• Participate in laboratory meetings, disseminate and promote results in the form of reports and oral presentations

Missions

Our team aims to improve the treatment of patients with liver cancer. For that, we are developing human tumor genomics approaches and pre-clinical models of drug sensitivity. The bioinformatics engineer will be responsible for analyzing genomic and biological data (genetic alterations, transcriptome, miRome, proteome, methylome). The objective is to develop analytical tools to study the correlations between molecular profiles and pharmacological responses in order to derive predictive biomarkers of efficacy and to better understand the determinants of therapeutic response.

POSITION PROFILE REQUIRED

Required professional skills and abilities

• Have skills in statistics and genomics  
• Proficiency in R, Perl, Python, (java and sql would be an advantage)
• Knowledge of docker-nextflow or equivalent would be an advantage
• Collection, processing and analysis of large-scale genomic data: whole-exome, RNAseq/single-cell RNAseq, methylome
• Ability to interact with people from different backgrounds and interests (biology, bioinformatics, etc.)
• Be autonomous and know how to work in a team
• Maintain a scientific and technological survey in his/her field of expertise
• Written and spoken English

Training and experience required

Master's degree (bac+5) in bioinformatics. Experience in bioinformatics in a biology laboratory would be desirable. Experience in genomic data analysis would be appreciated.

TYPE OF CONTRACT

12-month fixed-term contract, renewable for 24 months

Quota : 100%

Salary: According to Inserm salary scales, depending on qualifications and experience