Société Française de Bioinformatique

Mots-Clés

RNA splicing, networks, cancer

Description

This project is a funded collaboration (3 years) between Margherita Ghisi (CRCT), Manuel Diaz Munoz (Infinity) and Vera Pancaldi (CRCT) in Toulouse. The post is for a junior post-doc and will be shared between the Diaz Munoz and Pancaldi labs. 

It aims to explore the role of RNA splicing in the pro-survival metabolic adaptation and response to therapy of Acute Myeloid Leukemia cells. We will make use of cutting-edge transcriptomics and genetic engineering technologies in association with clinically relevant mouse xenografts models of AML. We will study unappreciated post-transcriptional mechanisms regulating AML metabolic plasticity and adaptive stress response underlying therapy resistance. The candidate will conduct alternative splicing analysis and interpret results in the context of regulatory networks.

Experience in NGS analysis is a must, experience in alternative splicing analysis, epigenomics and network science is a very big plus. 

The three teams are international and inclusive.