Mots-Clés

Trajectories, reprogramming, cancer, Scenic, Dorothea

Description

The Lavial Lab is seeking a talented postdoctoral scientist with strong background in bioinformatics to explore the cellular trajectories of oncogenic transformation and reprogramming in vivo. We recently developed a series of cellular and mice models to conduct multi-omic comparative analyses (see Huyghe A. et al., Nature Cell Biology 2022) (https://www.crcl.fr/en/citi-department/reprogramming-stem-cells-and-oncogenesis/ - Lyon university).

The candidate will integrate a dynamic and stimulating environment at the cancer research center of Lyon (CRCL). He/she will work in direct collaboration with the bioinformatics department on site (https://www.crcl.fr/en/platforms/gilles-thomas-bioinformatics-platform/ ).

Skills:

- The candidate will have experience in omics data analysis (with diploma in bioinformatics or biology). He/she will be able to work with R software (CRAN/Bioconductor) and will be ideally familiar with another language like Bash or Python. A previous experience in analyzing high-throughput sequencing data (RNA-seq/ATAC) will be an asset, as well as knowledge for single cell data analyses.

- Autonomy and ability to drive the project

- Organization and team player

- Excellent communication and writing skills

- Fluency in English

Recent publications:

-A. Huyghe, G. Furlan, J. Schroeder, E. Cascales, A. Trajkova, M. Ruel, F. Stüder, M. Larcombe, Y. Bo Yang Sun, F. Mugnier, L. De Matteo, A. Baygin, J. Wang, Y. Yu, N. Rama, B. Gibert, J. Kielbassa, L. Tonon, P. Wajda, N. Gadot, M. Brevet, M. Siouda, P. Mulligan, R. Dante, P. Liu, H. Gronemeyer, M. Mendoza-Parra, J. M. Polo, F. Lavial. Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity. Nature Cell Biology 2022.

-A. Huyghe, G. Furlan, D. Ozmadenci, C. Galonska, J. Charlton, X. Gaume, N. Combémorel, C. Riemenschneider, N. Allègre, J. Zhang, P. Wajda, N. Rama, P. Vieugué, I. Durand, M. Brevet, N. Gadot, T. Imhof, B. J. Merrill, M. Koch, P. Mehlen, C. Chazaud, A. Meissner, F. Lavial. Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling. Nature Cell Biology 2020.

-A. Puisieux, R.M. Pommier, A.P. Morel, F. Lavial. Cellular Pliancy and the Multistep Process of Tumorigenesis. Review. Cancer Cell 2018.