Mots-Clés

transcriptomics, single cell RNAseq, spatial transcriptomics

Description

Bioinformatic engineer position
at Institut Pasteur, Paris, France

Cancer immunology and immunotherapy
 

Paris, March 2023

Position
A bioinformatic engineer position is available in the Guermonprez lab at Institut Pasteur Paris (“Dendritic cells and adaptive immunity” Unit, Immunology Department). The Guermonprez lab investigates the role of dendritic cell subsets in regulating T cell responses (https://www.guermonprezlab.org).

Project
The Guermonprez lab investigates the cellular basis of anti-tumor immunity. We intend to understand cellular cross-talks between dendritic cells and anti-tumoral T lymphocytes in the context of cancer development and immunotherapies.
The main objectives of this project are:
- to delineate myeloid cells and T cell infiltrate diversity in preclinical models of cancer and clinical samples defining immune landscapes,
- to understand how myeloid cells impact on T cell localization within tumors,
- to identify new molecular pathways underpinning cellular interactions between T lymphocytes and myeloid cells,
- to evaluate the impact of existing and novel cancer immunotherapies on immune infiltrates.

Mission
The candidate will:

• Conduct analyses of experimental data generated in the lab (bulk RNAseq, scRNAseq, spatial transcriptomics) and publicly-available datasets.
• Present results in laboratory and collaborative meetings.
• Collaborate actively with scientists performing wet bench experiments (PhD, postdocs). 
• Interact with other bioinformatic engineers or researchers.
• Formalize results for publications and participate to the assembly of publication manuscripts.

Profile
We are looking for highly motivated individuals motivated to bring new insights into the biology of adaptive immunity against cancer.
The candidate is expected to have:

• A specialist training in bioinformatics at M2/Msc level, grandes écoles or PhD level.
• Dynamism, autonomy and drive.
• Good interaction skills with wet bench scientists and biologists in general.
• Enthusiasm for research on cancer immunology and immunotherapy.

Previous expertise with handling of transcriptomics data, single cell RNA sequencing datas, spatial transcriptomics or TCR sequencing at the single cell level will be appreciated. Examples of methodologies of interest for the project: SEURAT; SCENIC; CELLPHONEDB; NICHENET; CytoSPACE.

Contact & applications:
Pre-application informal inquiries are welcome.
Applications should be sent to pierre.guermonprez@cnrs.fr
“Dendritic cells and adaptive immunity” Unit, Immunology Department, Institut Pasteur.
For applications, please provide: 1 CV, 1 publication list, the email contact for 2 references.