Ingénieur F/H Développement multi-omics intégré

 CDD · Postdoc  · 24 mois    Bac+8 / Doctorat, Grandes Écoles   Inria - EPIONE · Sophia Antipolis (France)

 Date de prise de poste : 15 novembre 2023


biologie numérique, multi-omics, mitochondrie, machine learning, maladies rares, genetique, meta-data


A propos d'Inria
Inria est l’institut national de recherche dédié
aux sciences et technologies du numérique. Il
emploie 2600 personnes. Ses 200 équipes-
projets agiles, en général communes avec des
partenaires académiques, impliquent plus de
3500 scientifiques pour relever les défis du
numérique, souvent à l’interface d’autres
disciplines. L’institut fait appel à de nombreux
talents dans plus d’une quarantaine de métiers
différents. 900 personnels d’appui à la
recherche et à l’innovation contribuent à faire
émerger et grandir des projets scientifiques ou
entrepreneuriaux qui impactent le monde.
Inria travaille avec de nombreuses entreprises
et a accompagné la création de plus de 180
start-up. L'institut s'efforce ainsi de répondre
aux enjeux de la transformation numérique de
la science, de la société et de l'économie.

A propos du centre ou de la direction fonctionnelle
The Inria Sophia Antipolis - Méditerranée center counts 34 research teams as well as 7 support
departments. The center's staff (about 500 people including 320 Inria employees) is made up of
scientists of different nationalities (250 foreigners of 50 nationalities), engineers, technicians and
administrative staff. 1/3 of the staff are civil servants, the others are contractual agents. The majority
of the center’s research teams are located in Sophia Antipolis and Nice in the Alpes-Maritimes. Four
teams are based in Montpellier and two teams are hosted in Bologna in Italy and Athens. The Center is
a founding member of Université Côte d'Azur and partner of the I-site MUSE supported by the
University of Montpellier.

Contexte et atouts du poste
The project MITOMICS is funded by the Agence Nationale de la Recherche and will be in collaboration
with Université Côte d'Azur, the University of Angers and the University of Nantes.

Mission confiée
The goal of the project consists in developing innovative machine learning approaches to better
characterize the clinical and molecular heterogeneities of mithocondrial diseases, and identify
specific molecular signatures through the development of multi-omics analysis.
The project requires the integration of the developed tools within the MitoMatcher database, a
centralized national database dedicated to mithocondrial disease started, with currently more than
3,000 patients with multi-omics information.

Principales activités
Develop processing pipelines for genetics data and meta-data, and extraction of relevant
information such as heteroplasmy, mitochondrial haplogroups, population frequency, and as
well as the corresponding
disease-related phenotypes.
Develop machine learning methods allowing to effectively combine mtDNA variants,
nuclear variants (WES, WGS) and clinical phenotypes, to succesfully identify variants
associated to pathological traits
Access the available national databases and deploy the developed framework in compliance
with data privacy and access restriction.
Validate the methods by using relevant metrics
Communicate the work through scientific publications and dissemination initiatives
Interact with the project's partners and present the work's progress to the consortium


Technical skills and level required :
Good knowledge in Bioinformatics
Good knowledge in Machine Learning
Knowledge in biology and clinical applications

Languages :

Relational skills :
Strong interpersonal skills and ability to clearly present
Ability to relate to colleagues with different background

Other valued appreciated :
Relevant publication record is a plus

Subsidized meals
Partial reimbursement of public transport costs
Leave: 7 weeks of annual leave + 10 extra days off due to RTT (statutory reduction in working
hours) + possibility of exceptional leave (sick children, moving home, etc.)
Possibility of teleworking and flexible organization of working hours
Professional equipment available (videoconferencing, loan of computer equipment, etc.)
Social, cultural and sports events and activities
Access to vocational training

Contribution to mutual insurance (subject to conditions)

From 2652 € gross monthly (according to degree and experience)


Procédure :

Date limite : 20 décembre 2023



Offre publiée le 18 juillet 2023, affichage jusqu'au 20 décembre 2023