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Modélisation et inférence des processus de régulation intra/inter cellulaire en oncogénèse

 Stage · Stage M2  · 6 mois    Bac+5 / Master   Biologie Computationnelle du CRCL · lyon (France)

 Date de prise de poste : 1 septembre 2025

Mots-Clés

computational biology modeling insilico oncology

Description

Job description
The CRCL new Computational Biology department develops innovative systems biology services for the analysis of biological bigdata and modelling biological processes. It helps and supports research teams in their R&D, from the very early stages right through to clinical trials, by proposing optimal solutions and the rational design of new experiments based on simulations.

Mission
As a bioinformatics and modelling trainee, you will be working on simulation models that reproduce intra- and inter-cellular regulatory processes. Supported by experimental data, in particular spatial transcriptomic data, you will have to analyse these data, define a model, infer its parameters and propose a visualisation of the simulations. This work will be carried out in close collaboration with the CRCL’s research and bioinformatics teams.

Job description (activities) :
The trainee recruited will be responsible for :
1- Analysing OMIC data, in particular spatial transcriptomic data
2- Modelling intra/inter cellular regulatory processes
3- Infer models from experimental data
4- Exploring models: sensitivity analysis.

Profile required
We are looking for someone with a degree in engineering or a Masters with a strong bioinformatics and modelling component. Curiosity and a taste for transdisciplinarity will be highly appreciated.

Skills required
Systems skills (Unix)
Good knowledge of Python
Good knowledge of bioinformatics
Good knowledge of mathematical modelling and modelling
Fluency in scientific English, both written and read

Candidature

Procédure : Envoyer un mail aux contacts

Date limite : 31 août 2025

Contacts

 Arnaud Bonnaffoux
 arNOSPAMnaud.bonnaffoux@lyon.unicancer.fr

 Elsa Guillot
 elNOSPAMsa.guillot@lyon.unicancer.fr

Offre publiée le 18 juillet 2025, affichage jusqu'au 31 août 2025