Mots-Clés
RNA, simulations, molecular biology
Description
The In Silico Pharmacological Profiling team, under the supervision of Pr. Pasquali, is seeking a highly motivated postdoctoral researcher for an 18-month appointment at the BFA Laboratory, Université Paris Cité, under an INSERM contract.
Research Focus
The project centers on the characterization and identification of RNA binding pockets and their dynam-ic evolution within the large conformational ensembles adopted by RNA systems. The successful candi-date will:
• Develop a method for pocket identification based on our recent work on molecular interaction fields and geometric pocket characterization.
• Apply this approach to enhanced sampling simulations (molecular dynamics and path sampling) to monitor the “life cycle” of RNA pockets.
• Collaborate with an experimental group at Université Paris Cité performing SHAPE experi-ments on RNA aptamers, enabling integrative computational–experimental insights.
Candidate Profile
Applicants must hold a Ph.D. in one of the following fields:
• Theoretical Chemistry
• Bioinformatics
• Computational Physics
• Theoretical Biophysics
• Computational Biology
Essential qualifications:
• Strong experience with biomolecular simulations (MD, enhanced sampling).
• Proficiency in Python programming and method development.
• Motivation to work in an interdisciplinary environment, collaborating with both computational and experimental groups.
Offer
• Duration: 18 months
• Net Salary: €2,500/month (including full welfare and pension benefits)
• Location: BFA Laboratory, Université Paris Cité, Paris, France
Application
Interested candidates should send the following documents in a single PDF file:
1. A detailed CV (including publications and relevant skills).
2. A cover letter outlining motivation and research experience.
3. Contact information for two referees.
Applications should be sent to Pr. Pasquali at: samuela.pasquali@u-paris.fr
Application review will continue until the position is filled.