Mots-Clés
systems biology
paediatric brain cancers
gene regulation
Description
About Cell-ID
The Cell-ID program focuses on uncovering the molecular mechanisms that govern cell fate determination during neural development and how their disruption contributes to childhood brain cancers.
Our goal is to design strategies for a cell-based interceptive medicine: targeting the earliest cellular and molecular events in cancer to prevent disease progression.
Led by CNRS and Inserm, in collaboration with major French institutions and international partners, Cell-ID integrates omics technologies, advanced imaging, and computational modeling to study genome function and 3D nuclear organization in neural tissues under normal and pathological conditions. By combining cutting-edge experimental tools with predictive models, the program aims to define and modulate cell trajectories during neural development.
About this project
Computational Systems Biology of Polycomb regulation in pediatric brain cancer
Giacomo Cavalli and Daniel Jost
The Polycomb machinery is essential in regulating gene silencing during embryogenesis and development, through the coordinated action of transcription factors, histone modifying enzymes and architectural proteins. The initiation of several pediatric brain cancers has been associated with perturbations in such a machinery, which have important system-scale consequences on gene regulation. While the molecules whose functions may be impaired have been identified, how such an impairment affects mechanistically gene expression locally and at the systems scale remains elusive.