Mots-Clés
Molecular modeling
Allostery
Normal Mode Analysis
Ion channels
Description
A 12-month post-doctoral position is available at the LBPA, Ecole Normale Supérieure Paris-Saclay in Gif-sur-Yvette. The laboratory is located in the quickly developing Paris-Saclay campus. We seek a highly motivated and skilled post-doctoral researcher to join our interdisciplinary team. The successful candidate will be a key member of the KirFlex research project, funded by the French National Research Agency (ANR) in collaboration with the IMPMC at Sorbonne Université in Paris. She/he will work on a cutting-edge project focused on exploring the conformational dynamics and allosteric regulation networks of an inward-rectifying potassium channel (Kir2.1), integrating molecular simulations and experimental data (cryo-EM, sm-FRET). This project aims to provide a comprehensive model of Kir2.1 allosteric regulation, with potential therapeutic applications.
The candidate will use enhanced sampling methods (in particular hybrid Molecular Dynamics and Normal Mode simulations) to explore the conformational dynamics of wild-type and mutant channels and characterize the allosteric networks responsible for channel modulation, and the influence of various modulators. She/he will collaborate closely with experimentalists to interpret and integrate several experimental data.
The ideal candidate should possess a combination of the following qualifications, although not all are mandatory:
Ph.D. in Computational Biophysics, Structural Biology, Bioinformatics, or a related field.
Strong background in molecular dynamics simulations.
Experience in the statistical analysis and visualization of simulation results.
Excellent programming skills (Python).
Strong analytical and problem-solving abilities.
Ability to work independently and collaboratively within a multidisciplinary team.
Strong communication skills and a track record of scientific publications.
Experience with cryo-EM data interpretation, flexible fitting techniques, and normal mode analysis are appreciated.
The position is available starting September 2026.
Interested candidates should submit their application at https://emploi.cnrs.fr/Offres/CDD/UMR8113-CRICEL-009/Default.aspx