Mots-Clés
bioinformatics
machine learning
pharmacogenomics
anticancer drug discovery
cancer
Description
AI Engineer / Bioinformatician – AI for Drug Discovery
Join the AI for Genome Interpretation (AI4GI) group at IGMM-CNRS, Montpellier, for a 13-month engineer position with the possibility of renewal for up to 3 additional years.
You will work at the intersection of machine learning, bioinformatics, chemoinformatics and cancer biology, in a collaboration between Raimondi and Hahne laboratories. The goal is to develop AI methods to predict drug responses in treatment-resistant CMS4 colorectal cancer and accelerate the discovery of new therapeutic molecules.
Your work will include:
- Developing novel PyTorch-based machine learning methods for drug-response prediction.
- Integrating pharmacogenomic, molecular and phenotypic data from resources such as GDSC, DepMap and CCLE.
- Developing molecular representations using chemoinformatics, molecular fingerprints and graph-based approaches.
- Building an Active Learning, experiment-in-the-loop framework that selects the most informative compounds for experimental validation.
- Applying the resulting models to the virtual screening of 78 billion compounds in the Enamine REAL chemical library.
- Working closely with experimental cancer biologists to iteratively improve the computational models.
We are looking for someone with strong Python and machine learning skills, a solid understanding of mathematics, statistics and deep learning, and familiarity with scientific computing and Linux. Experience in bioinformatics, chemoinformatics, pharmacogenomics, drug-response prediction, GNNs, Active Learning, uncertainty estimation or HPC/GPU computing is a strong advantage.
This is an opportunity to develop new AI methodologies with direct applications to drug discovery, while working in a highly interdisciplinary and international research environment at IGMM-CNRS in Montpellier.
Contract: 13 months, renewable up to 3 years
Salary: depending on experience, from around €2,521 gross/month
Benefits: 44 days annual leave/RTT, remote-working support, 75% public transport reimbursement and mobility allowance up to €300